Palace's development side will kick-off the club's pre-season schedule when they face East Grinstead Town on Friday night at the GAC Stadium.
With the majority of the first-team squad currently undergoing warm weather training in Portugal, U21s manager Gary Issott will be hoping that in their absence his youngsters can stake a claim to be involved in the top flight during the campaign.
The game starts at 7.30pm with ticket prices set at £8 for adults, £15 for an adult and two children, £20 for two adults and two children and £5 for senior citizens and under 18s. No tickets can be bought in advance.
On facing the newly-promoted Eagles, East Grinstead chairman Richard Tramontin said: "Ian Holloway's squad will have only just returned for pre-season so there may not be any first-team players involved but Palace have always had a very strong academy set-up and one of their graduates, Wilfred Zaha, was the inspiration behind their promotion run.
"We may be be seeing Palace's stars of the future and I'm sure the game will be well supported as there are a lot of Palace fans in the area who will look forward to the game."