Former Palace players Simon Osborn and Robert Quinn will once again don the famous red and blue to help Eagles fans try and beat their Brighton counterparts.
On Friday May 2nd supporters from both clubs will meet at the Dripping Pan stadium in Lewes for the 13th annual Robert Eaton Memorial Fund match.
Palace's Crystal Girls cheerleaders will also be there to cheer the sides on, as will Pete and Alice the Eagles.
The Seagulls currently lead 8-4 in the series and the Palace boys will be keen to claw back a result - with the help of Osborn and Quinn.
The REMF fund was set up after Brighton fan Robert Eaton was killed in the 9/11 attacks in New York City in 2001 and has since raised more than £100,000 for disadvantaged children in America, Sussex, Croydon and Africa.
The games are fiercely contested with plenty of tasty challenges, just ask former Albion star Peter Ward who was kicked all over the park during his first involvement in the annual game in 2009 but will be be turning out for the Seagulls this year again.
Organising the Palace team this year is Five Year Plan editor Jim Daly and he is desperate for the Eagles to win.
"We've lost the last two years to slender score lines so it's time to bring the trophy back to South London," he said.
“Obviously, it is a brilliant cause, which helps underprivileged kids in Sussex, Croydon and America and it’s great to be able to help out each year, but I’d be lying if I said the result didn’t matter.
"We're delighted Simon and Robert are giving up their time to help us out too in the true spirit of charity and what the night is all about!"
To see if Osborn and Quinn can help the Palace fans to a victory this year come down to the Dripping Pan in Lewes on Friday May 2nd. Kick-off is 7.45pm and entry is £5 with U16s £2 or getting in free if accompanied by an adult.
For more information or to donate to the fund visit remf.org.uk