The on-loan Blackpool winger was substituted at half time during the Eagles' last away game at Swansea City, before being introduced from the bench on 66 minutes during the 1-0 defeat to Southampton last week.
Ince's inclusion in place of Jason Puncheon is one of two changes made by manager Tony Pulis for the clash at the Stadium of Light, with Adrian Mariappa also returning to first team action.
The Jamaican international full back has not started a Premier League fixture since the 10 victory over Hull City on 28th January.
Crystal Palace: Speroni, Mariappa, Dann, Delaney, Ward, Bolasie, Dikgacoi, Jedinak, Ledley, Ince, Murray.
Sunderland: Mannone, Bardsley, Alonso, O'Shea, Brown, Bridcutt, Ki, Larsson, Johnson, Borini, Fletcher.