Both sides head into this game looking to end a spell of poor form, with United suffering their worst start to a Premier League season having claimed just 13 points from their opening 10 games.
Neil Warnock's side are looking to claim a first league victory at the Theatre of Dreams since 1989 and will seek solace in the fact that the Red Devils have kept just two clean sheets in their last 12 league games at home.
Louis van Gaal's men didn't enjoy the best of derby days last weekend as they were pipped 1-0 by Manchester City, and recorded draws against Chelsea and West Bromwich Albion in their previous two matches.
Manchester United: Chris Smalling is suspended for the game after being sent-off in last weekend's game at the Etihad Stadium, and Marcos Rojo also dislocated his shoulder in that encounter and is out for two months.
United's defensive injury woes stretch further with Jonny Evans, Rafael and Phil Jones all out, but Michael Carrick returned from an ankle injury and is set to fill in at centre-back alongside youngster Paddy McNair.
Also in a busy treatment room in Manchester, Radamel Falcao has missed the last two outings with an unspecified knock and Ashley Young is struggling for full fitness with a groin problem.
Crystal Palace: Mile Jedinak is set to miss his first Premier League game for the Eagles through suspension, having featured in all of their previous 48 matches since returning to the top flight last year.
Wilfried Zaha is ineligible to play against his parent club, but Damien Delaney could be back in the fold after missing the defeat to Sunderland on Monday night through illness.
Referee: Chris Foy
Assistants: H Leonard and A Garrett
Fourth Official: L Mason
LAST MEETING AT OLD TRAFFORD
14th September 2013
Manchester United 2-0 Crystal Palace
Robin van Persie's controversial penalty helped Manchester United beat 10-man Palace, giving then-Reds boss David Moyes a first home league win.
The Dutchman slotted in a 45th-minute spot-kick after Kagisho Dikgacoi was adjudged to have fouled Ashley Young, despite the contact taking place outside the area.
Dikgacoi was red-carded, and despite hanging on Wayne Rooney netted a sublime free-kick to seal the victory for United.
Watch highlights here on Palace Player.
Tickets in the Palace end for this game are SOLD OUT. Please don't travel up to Manchester if you don't currently have a match ticket.
Manchester United to win: 2/7
Crystal Palace to win: 9/1
Odds courtesy of SkyBet.
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