Only one change for Palace in the starting line-up, with Wilfried Zaha returning from suspension and replacing an injured Mile Jedinak.
On the bench, Speroni, Bamford and Gayle are replaced by McCarthy, Mariappa and Lee.
Southampton meanwhile have made two changes from their draw at home to Aston Villa, with goalkeeper Stekelenburg out through injury and replaced by Gazzaniga, and Romeu starting upfront as Pelle drops to the bench.
Palace: Hennessey, Ward, Dann, Delaney (c), Souare, Cabaye, Zaha, Bolasie, McArthur, Puncheon, Wickham. Subs: McCarthy, Mariappa, Kelly, Lee, Mutch, Campbell, Chamakh.
Southampton: Gazzaniga, Cedric, Yoshida, Fonte (c), Long, S.Davis, Mane, Wanyama, Romeu, Van Dijk, Bertrand.