Having beaten Dover Athletic in the third round, Palace have been drawn away to Champions League-chasing Southampton in the FA Cup, hoping to make the fifth round for the first time in five years, and for just the second occasion in the last decade.
They meet a Saints side who needed a replay to edge out Ipswich Town at Portman Road last week, with Shane Long netting the game's only goal after they'd been held to a 1-1 draw at St Mary's at the start of the month.
Southampton were in formidable form when they beat Palace at Selhurst on Boxing Day, and since then have drawn against Chelsea, beaten Arsenal and recorded back to back away victories against Manchester United and Newcastle United as they continue to stay in the top six mix.
Their home form is formidable having lost there on just two occasions in the league this season, conceding only seven times, but the Eagles are a much more confident outfit than the one that lined up against Ronald Koeman's men four weeks ago.
Southampton: Toby Alderweireld, Morgan Schneiderlin and Victor Wanyama will all miss out through injury.
Zambian striker Emmanuel Mayuka is away in the Africa Cup of Nations, as well as winger Saido Mane who represents the Ivory Coast.
Crystal Palace: Alan Pardew has suggested that he has a fully fit squad to choose from, which may suggest that Marouane Chamakh has recovered from the hamstring injury that has kept him out for the past six weeks.
Yannick Bolasie and Mile Jedinak are still away on international duty, with the Eagles skipper likely to be missing until the Leicester City game next week as Australia have made it into the latter stages of the Asian Cup.
Having started Wayne Hennessey, Barry Bannan and Glenn Murray in the last round, it remains to be seen if Pardew will shuffle his pack to see some more of his fringe players in action.
Referee: Jon Moss
Assistants: M Wilkes and C Powell
Fourth Official: J Linington
LAST MEETING AT ST MARY'S
28th September 2013
Southampton 2-0 Crystal Palace
Record signing Dani Osvaldo scored his first goal for Southampton as they beat Crystal Palace to climb to fourth in the Premier League.
Osvaldo found the net shortly after the restart with a neat low finish from just inside the box, and Rickie Lambert made it 2-0 shortly after with a fine 25-yard free-kick.
Watch highlights here on Palace Player.
This game is sold out.
The club had an allocation of just over 3,000 for this match and there will be no further tickets available.
Please do not travel if you haven't purchased a ticket for the game.
For more information on St Mary's Stadium, including travel directions, check out our away day guide here
Please be advised that due to a burst water main, St James Road, between Wellesley Road and Oakfield Road is closed.
Traffic travelling along Wellesley Road will be turned at Station Road, West Croydon onto London Road.
Traffic wishing to turn right from Whitehorse Road into St James Road will be diverted around Newgate and down Station Road onto London Road.
Congestion is expected in this area, including Bedford Park and Lansdowne Road.
Please consider alternative routes where possible.
Southampton to win: 8/13
Crystal Palace to win: 9/2
Odds courtesy of SkyBet.
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