Having won at this venue in the cup 38 days ago, Palace go in search of their first ever win against Southampton in the Premier League era.
In their 11 games to date since 1992, Palace have drawn four and lost 11 against the south coast side, but are unbeaten in their last seven away games, winning all five under Alan Pardew's reign including the 3-2 win against Ronald Koeman's side in January.
Since then the Saints have picked up just four points and scored only once, and it is five hours and four minutes since they scored a home league goal at St Mary's.
Three goals from set-pieces against West Ham United last weekend saw Palace reach 17 goals from that method this season which is a league high, but the Saints have only conceded one header this term, albeit it was Scott Dann who nodded in when the sides met at Selhurst on Boxing Day.
Interestingly, whilst Palace have won 15 points from losing positions, Southampton have only dropped two when leading, the best in the division.
Southampton: Centre-back Toby Alderweireld could return to the Saints side after missing the last seven games with a hamstring injury.
Their only other injuries are long-term casualties Jay Rodriguez and Emmanuel Mayuka, although Graziano Pelle is under pressure after failing to find the net since the sides last played in the FA Cup fourth round in January.
Crystal Palace: Glenn Murray will serve his one-match ban in this game after picking up a red card against West Ham United on Saturday.
He joins fellow strikers Marouane Chamakh, Fraizer Campbell, and Yaya Sanogo on the sidelines who both have hamstring injuries, and Jordon Mutch is awaiting the results of the thigh injury he picked up on the weekend. Lee Chung-yong is also still out.
Mile Jedinak has until 6pm today to appeal the FA charge he was handed yesterday, if he doesn't he will miss the next four games, starting tonight.
Referee: M Atkinson
Assistants: A Garrett and M Wilkes
Fourth Official: R East
LAST MEETING AT ST MARY'S
24th January 2015
Southampton 2-3 Crystal Palace
FA Cup Fourth Round
Palace twice battled back from a losing position to book their place in the fifth round of the FA Cup after seeing off Southampton 3-2 thanks to a Marouane Chamakh brace and Yaya Sanogo’s first goal for the club.
A breathless first half saw Alan Pardew’s side slip behind early doors thanks to a Graziano Pelle goal but the returning Chamakh quickly pulled his side level. Scott Dann then conceded an own goal before Sanogo struck, and then Chamakh added a third on 38 minutes to give the Eagles a lead they’d never surrender.
Pardew’s side held on to clinch their fourth win in a row under his management and knock the Saints out of the cup on their own patch in an impressive display - a far cry from their defeat at Selhurst to the same opposition less than a month previously.
Tickets are still available from the Palace box office until noon today (Tuesday 3rd March)
Concessions (Over 65s & 17-21 year olds) £30
11- 16 year olds - £21
Under 11s - £12
to purchase your tickets or you can call the box office on 08712 00 00 71.
For information on St Mary's Stadium, including directions, check out our guide here
Southampton to win: 7.10
Crystal Palace to win: 4/1
Odds courtesy of SkyBet.
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