Joe Ledley scored his first goal for Wales in over five years but the Red Dragons would ultimately fall to a 3-2 defeat in an entertaining game in Cardiff on Friday night.
The Palace midfielder was perfectly placed to slide the ball home to score his fourth international goal after Joe Allen saw his penalty saved by Jasper Cillessen, which leveled the scores just before half-time as Wales cancelled out Wolfsburg striker Bas Dost's opener.
Joined by Eagles teammates Wayne Hennessey and Jonny Williams in Chris Coleman's starting line-up, Ledley would be withdrawn just after Arjen Robben put the Dutch back in front, but his replacement Emyr Huws headed in a second equaliser on 70 minutes.
After Williams and Hennessey were also replaced, playing 60 and 74 minutes respectively, a much-changed home side would succumb to defeat when Bayern Munich man Robben completed his brace nine minutes from time for a Holland team who, unlike Wales, won't be featuring at Euro 2016 next summer.
The defeated ended Wales' two year run without a loss at the Cardiff City Stadium, and after the game Ledley admitted that he was sad to see that statistic go.
"We were all obviously gutted about the result," he said. "We were missing Aaron Ramsey and Gareth Bale but I still thought we put in a good performance against a good team and on another day we would have won that.
"I was delighted to score, I haven't scored for Wales for a long time and I was just happy to get on the scoresheet and hopefully get some more.
"We're gutted with the result and need to move on quickly so we'll be looking forward to the next games in March."
Meanwhile Yohan Cabaye won his 43rd cap for France as Les Bleus beat Germany 2-0 in Paris. Cabaye came on for the final three minutes although the game was overshadowed by the events that took place in the city on Friday night.
He could be set to play against England on Tuesday night with the FA confirming that the Wembley friendly between the two teams is still set to go ahead.