Alan Pardew was left to reflect on missed chances early in the game as his side were not able to come back from conceding two in the first half.
"It was a tough night for us, we were short on numbers tonight and the team lacked a bit of balance, A lot of our flair players were injured but Manchester City played well tonight and took their chances and unfortunately we didn't. Almost every time City had a chance they punished us, particularly in the first 60 minutes and that was very much the story.
"We had three or four good chances and it is not often that you get that so you have to take them and we were then vulnerable particularly when they go two ahead. We should have scored before they did and then at 2-0 had a great chance but we didn't make the most of them. They deserved the victory so we have no complaints."
Attention now turns to the weekend and the visit of Manchester United to Selhurst Park.
"We now get ourselves focused on the game on Saturday and need to make sure we get a few bodies back for the game. We need to put our strongest team out against them, we had a few back tonight with Joel Ward getting some minutes and Dwight Gayle back from suspension. We have some problems with a few as Jason Puncheon has been ill and Yohan Cabaye has a knock but fingers crossed they will be back for the weekend. Connor Wickham and Marouane Chamakh are training plus we have our fingers crossed for Pape Souaré being back on Saturday."
There were travel issues on the M6 as both Manchester clubs played at home which led to delays for visiting fans and this was acknowledged by the manager.
"I know some of the fans had trouble getting here tonight, so we'd like to say thank you and I hope we can repay them later in the season, a thank you to them all."