The Eagles will be looking to extend their three match unbeaten run when they travel to north London for their final capital clash of the campaign as they take on an Arsenal side still clinging on to their title hopes.
This game comes sandwiched inbetween their main rivals' matches, with Leicester City in action in the early Sunday game and Tottenham Hotspur taking on Stoke City on Monday, meaning the Gunners will be aiming to crank up the pressure should the Foxes slip up.
Their form has been patchy of late which has seen them fall 13 points behind Leicester, with last weekend's 3-3 draw against West Ham United - after being two goals ahead - potentially proving critical, so Wenger knows his side cannot afford to drop any more points.
Palace meanwhile have a miserable record against the Gunners, having won just once in their 13 Premier League meetings, and haven't won a league game on the road in their last seven matches, stretching back to the 2-1 victory at Stoke in December.
Arsene Wenger: “It is a London derby and now they [Palace] should be completely safe. They are a good team with a lot of offensive potential. They have strong individuals like Zaha, Bolasie, Wickham and Adebayor.
“We need to rectify the fact we conceded three at West Ham. We need a strong run now. There is pressure but a lot of pressure on the teams around us.
“It is perceived the title is over but I don’t think that completely. We have to fight from now until the end of the season."
Arsenal: Jack Wilshere and Tomas Rosicky played for the Gunners' under-21s in midweek but it is unlikely they will be included in the matchday squad to face the Eagles.
Santi Cazorla and Alex Oxlade-Chamberlain are nearing full fitness but this game will come too soon for them, while Wenger has a decision to make regarding whether to re-install Petr Cech between the posts ahead of David Ospina.
Crystal Palace: Dwight Gayle is set to miss out after coming off at half-time against Everton, but it is hopeful he will be fit for next weekend's FA Cup semi-final, and Wilfried Zaha has a knock but should be OK.
James McArthur could be the next to return for the Eagles after returning to training, but Alan Pardew has penciled him in for Wednesday trip to Manchester United instead.
Former Arsenal man Marouane Chamakh is Palace's only other injury concern, but he is out for the remainder of the season with a torn adductor.
HEAD TO HEAD
|Arsenal wins||Draws||Palace wins|
Arsenal have won none of their three London derbies at home in the Premier League this season (D1 L2).
Palace have taken fewer points in London derbies (4) than any of the clubs from the capital this season.
Former Gunner Emmanuel Adebayor has scored on two of his last three appearances as a visiting player at the Emirates.
Wenger's men have shipped just eight goals in their last 14 Premier League matches at the Emirates.
Arsenal's next victory in the Premier League will be their 500th; only Man Utd (582) have won more often in the competition.
Roger East takes charge of his first Palace game since January 2015 when Everton won 1-0 at Selhurst Park. He has overseen two Arsenal games this season which saw them beat Bournemouth and Burnley at home.
Referee: R East
Assistants: R West and M Scholes
Fourth Official: M Dean
LAST MEETING AT THE EMIRATES STADIUM
16th August 2014
Arsenal 2-1 Crystal Palace
Aaron Ramsey scored in stoppage time to break the resolve of Crystal Palace and give Arsenal a winning start to their league campaign on the opening day of the season.
Managerless Palace looked set for a point but had forward Jason Puncheon sent off for a second offence in the 89th minute before Ramsey pounced.
The visitors took a shock first-half lead when Brede Hangeland headed in.
The Gunners equalised just before the break when Laurent Koscielny nodded home from Alexis Sanchez's free-kick.
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