With a place in the FA Cup final now secure, the Eagles will be looking to finish off their Premier League campaign on a high to build momentum towards Wembley in three weeks' time.
The first of three league games before then start at St James' Park where Alan Pardew will make his first return since leaving the Magpies for Palace in January 2015, having spent over four years with the north-east club.
Rafael Benitez's recent appointment has galvanized the Toon Army who are right in the middle of a relegation fight alongside Sunderland and Norwich City, with the Eagles aiming for at least the solitary point that will see them reach the magical 40 mark.
In the corresponding fixture last November Palace chalked up their biggest ever win in the Premier League when they thumped Steve McClaren's outfit 5-1, but things will probably be much closer this time round with Newcastle unbeaten in their last three games, and only losing once at SJP in 2016.
Rafael Benitez: "We know we can beat anyone, especially at St James' Park.
"If we show the same passion, character and intensity that we have in recent games, I think we will win matches.
"We need to believe because we've set the standard in the past few games and we need to keep it."
Newcastle United: Yoan Gouffran could be available for selection again for the Magpies, and Steven Taylor is also close to fitness.
However captain Fabricio Coloccini and Daryl Janmaat remain out as well as long-term injury victims Tim Krul, Rob Elliot and Massaido Haidara.
Crystal Palace: Pardew's only concern is Wilfried Zaha who has a hamstring strain, with the Eagles' only other casualty is Marouane Chamakh who is out for the remainder of the season.
HEAD TO HEAD
|Newcastle wins||Draws||Palace wins|
Newcastle striker Papiss Cisse has scored in all three of his Premier League matches against Palace.
Emmanuel Adebayor has scored six goals and assisted six more in his last nine league games against Newcastle United. He jointly holds the Premier League record for most assists in a single game (four for Spurs v Newcastle; February 2012).
The Magpies have won more points in their last three Premier League games (5) than they did in their previous 10 (4).
Newcastle are unbeaten in their last three games (W1 D2 L0) and they haven't gone four games unbeaten in the Premier League since Alan Pardew's tenure (six games in Oct-Nov 2014).
The Eagles haven't won a Premier League away game since December 19th 2015; they have picked up just five points in nine road trips since (W0 D5 L4).
Mike Dean takes charge of this game - he's overseen three Palace league games this season which have resulted in a win, a draw and a loss for Pardew's side - the 1-0 loss at Leicester, the 1-0 win against Southampton and the 1-1 draw at Swansea. He was also in the middle for the FA Cup quarter-final victory at Reading.
Referee: M Dean
Assistants: S Long and S Burt
Fourth Official: R Madley
LAST MEETING AT ST JAMES' PARK
30th August 2014
Newcastle United 3-3 Crystal Palace
Wilfried Zaha's fierce 95th-minute shot ensured Neil Warnock began his second stint in charge of Crystal Palace with a dramatic draw at Newcastle United.
Palace led twice, through Dwight Gayle's close-range finish inside 30 seconds and Jason Puncheon's volley, but Daryl Janmaat's scrappy effort and Rolando Aarons's header levelled.
A third league defeat looked likely when Mike Williamson jabbed Newcastle ahead from two yards after 88 minutes before Zaha on his second debut pounced.
Tickets for this game are still available for Season Ticket Holders and Paid Members, with no points requirement, at eight per person.
Over 65s and students: £24
Juniors (U18): £15
To purchase your tickets online, please click here.
Coaches departs at 6.30am from Selhurst Park, priced at £40.
For directions on how to get to St James' Park, read our away travel guide here.
For more information on the ground, click here.
Live commentary of all 90 minutes from St James' Park will be available on Palace Player. Click HERE to log in or sign up.
There will also be constant updates throughout the day at @CPFC on Twitter.