Crystal Palace have made three changes to their side from last week’s defeat at Swansea City, with Joe Ledley replacing the suspended Yohan Cabaye in central midfield.
As well as the Frenchman, the Eagles will take to the field without the injured Connor Wickham who is replaced by Andros Townsend, and Martin Kelly who sees Damien Delaney take his place, with Joel Ward reverting to left-back in what will be a familiar 4-2-3-1 shape for the hosts.
Southampton meanwhile have made one change to their side that beat Everton last Saturday, with Sofiane Boufal replacing teenager Josh Sims, who drops to the bench.
Palace: Hennessey, Tomkins, Delaney, Dann, Ward, McArthur, Ledley, Zaha, Puncheon, Townsend, C. Benteke. Subs: Speroni, Fryers, Kelly, Flamini, Lee, Sako, Campbell.
Southampton: Fraser, Soares, van Dijk, Fonte, Bertrand, Ward-Prowse, Romeu, Hojbjerg, Boufal, Redmond, Austin. Subs: Taylor, Yoshida, McQueen, Clasie, Davis, Sims, Long.