The Eagles take on the Potters for the second time in two months, having beating Mark Hughes' side just 42 days ago at the Britannia Stadium thanks to Chung yong-Lee's wondergoal in the dying stages.
However that proved to be the Eagles' last taste of success in the Premier League, but their victory over Southampton at St Mary's at the start of the month set up this tie against the Staffordshire side at Selhurst.
Since the last meeting Stoke meanwhile have won four times in all competitions but suffered penalty shoot-out heartbreak in midweek against Liverpool as they exited the Capital One Cup at the semi-final stage, despite winning 1-0 at Anfield.
The two sides met at Selhurst Park in the third round three years ago which ended in a 0-0 stalemate, with Stoke winning 4-1 after extra-time in the replay.
Mark Hughes: "It has been a big period in the season for us and we'll have to go again at Selhurst Park but we'll be ready for it, there's no doubt about that.
"We have to be mindful that we played 120 minutes on Tuesday night and that might put a few of the guys at risk.
"That's something we'll work through; we've got good squad depth and I will pick a team that I think will beat Palace. It won't be easy because they are a decent side and have good threats and at home in the FA Cup they will want to do well.
"But given the confidence we have from Tuesday night we'll go there in good heart. I've no doubts the players will be ready to go again and there won't be any hangover from the disappointment of missing out on Wembley, more a determination to try and get there in a different competition."
Crystal Palace: New signing Emmanuel Adebayor has been ruled out of a starting spot by Alan Pardew, but the striker could possibly take a place on the bench if he proves his fitness to the Eagles boss.
Bakary Sako and Yannick Bolasie remain out for the foreseeable future with hamstring and knee injuries.
Stoke City: Ryan Shawcross has had a re-occurrence in the back injury that kept him out for the early part of this season and will miss the next fortnight, and Marko Arnautovic will have to be assessed after limping off at Anfield in midweek.
Charlie Adam is definitely out though after he came off against Liverpool with a torn calf and is out for six weeks, and Geoff Cameron is also out with an ankle ailment.
Goalkeeper Jakob Haugaard could play after starting in the third round at Doncaster Rovers whilst the likes of Marco van Ginkel, Joselu, Phil Bardsley and Mame Diouf could feature.
HEAD TO HEAD
|Palace wins||Draws||Stoke wins|
Having overseen the 1-0 defeat to Aston Villa earlier this month, Mark Clattenburg takes charge of the Eagles again for this cup tie. He also refereed the 3-1 home loss to West Ham United in October.
Referee: M Clattenburg
Assistants: M Scholes and S Ledger
Fourth Official: S Hooper
LAST MEETING AT SELHURST PARK
13th December 2014
Crystal Palace 1-1 Stoke City
Crystal Palace and Stoke fought out a scrappy draw after exchanging goals within two minutes early in the match.
James McArthur grabbed his first goal since joining Palace in September with a header that looped over Stoke goalkeeper Asmir Begovic.
But Peter Crouch equalised from close range just 92 seconds later when he latched on to a kind deflection.
Other chances were scarce, but Palace keeper Julian Speroni denied McArthur with a fine save after the break.
Tickets are still available for this game, and are priced at:
Students, 18-21 year olds & over 65s: £10
Juniors (under 18) : £5
The above prices do not include the Directors Box.
Season ticket holders in Block U of the Arthur Wait Stand who will be offered alternate seats for this match.
Season ticket holders and pre-paid members can purchase up to four tickets for this match
For your convenience your season ticket can be loaded onto your season cards, however you could also choose an e-ticket or paper ticket option, either from the drop down menu online or by stipulating this preference if calling /visiting the box office.
To book online, click here or call 08712 00 00 71.
Live commentary of all 90 minutes from Selhurst Park will be available on Palace Player. Click HERE to log in or sign up.
There will also be constant updates throughout the day at @CPFC on Twitter.