Palace continue to endure a sticky spell in the Premier League, having gone four consecutive games without scoring, drawing two of those games 0-0 and losing the most recent two outings away to Aston Villa and Manchester City.
Tottenham Hotspur sit fourth in the table and look likely to be one of the contenders for elite European football, if not the title, come May time.
It was this fixture last season that saw Alan Pardew get off to a winning start in the league as Palace boss, so the Eagles manager will be hoping for a similar response from his men as they host Mauricio Pochettino's high-flying north Londoners.
Mauricio Pochettino: "It's a very difficult place [to go]. Crystal Palace have a very strong team. Always it's difficult. Last season it was difficult for us, so it's a good challenge to go and to try to win the game."
"We are in a moment where we need to take the three points to settle our place high up the table. I think it's a very important game for us and it will be difficult."
Crystal Palace: Dwight Gayle has trained again this week, but Alan Pardew has said it will be too early for the striker to make a return to the first team. Yannick Bolasie and Bakary Sako are both out until late February, meaning that Pardew will have the same pool of players to choose from as he did for the trip to Manchester City last Saturday.
Tottenham Hotspur: Ryan Mason and Nabil Bentaleb are the only confirmed absentees for Spurs, though Pochettino may look to rotate his squad, having played against Leicester City on Wednesday night in an FA Cup replay.
Palace have failed to score in four of the last five league meetings with Spurs, but did beat them 2-1 at Selhurst in January last season.
Spurs are unbeaten in their last nine away league games (W4 D5 L0).
The Eagles have won just two of the last seven league matches at Selhurst Park (W2 D2 L3), failing to score in four of the last six.
The last nine league meetings between Spurs and Crystal Palace have seen 17 goals scored, all of them in the second half.
Martin Atkinson will take charge of this London derby, having last refereed Palace during the 1-0 home defeat to Sunderland in November. He has handed out 71 yellow cards and awarded one penalty in the Premier League this term.
Referee: M Atkinson
Assistants: M Mullarkey, S Long
Fourth Official: J Linington
LAST MEETING AT SELHURST PARK
10th January 2015
Crystal Palace 2-1 Tottenham Hotspur
Alan Pardew's first league game as Palace boss saw the home side go one behind in the second half thanks to a goal from Spurs' talismanic forward Harry Kane. The England international arrowed a low drive into the bottom corner of the Whitehorse Lane end goal.
Dwight Gayle's penalty drew Palace level in front of the Holmesdale, before a lovely swept finish from Jason Puncheon after good work out wide from Wilfried Zaha settled the tie in the Eagles' favour.
Tickets for this game are SOLD OUT.
Live commentary of all 90 minutes from Selhurst Park will be available on Palace Player. Click HERE to log in or sign up.
There will also be constant updates throughout the day at @CPFC