Whilst this will be Crystal Palace's second appearance in an FA Cup final, Manchester United have reached what is a record-equalling 19th visit to the showpiece final, aiming to join Arsenal on 12 wins.
However it has remarkably been 12 years since United last put the famous piece of silverware in the Old Trafford trophy cabinet, a run stretching back to their 4-0 dismantling of Millwall in the 2004 final.
They haven't won the competition at Wembley Stadium since they completed the second leg of their famous Treble in 1999, despite playing in the first final at the rebuilt ground in 2007 when they lost 1-0 to Chelsea, which also happened to be their last final appearance.
However Louis van Gaal will be hoping that will all change on Saturday when they take on Palace, having endured some tough ties on their way to the final. Here is how they did it:
Manchester United 1-0 Sheffield United
Saturday 9th January
Man Utd: Rooney (pen) 90+3
Man Utd: De Gea, Darmian, Smalling, Blind, Borthwick-Jackson, Fellaini (Pereira 78), Schweinsteiger, Mata (Lingard 60), Herrera (Depay 60), Martial, Rooney. Subs not used: Romero, Varela, McNair, Keane
Sheffield United: Long, Brayford, Edgar, Collins, McEveley (Reed 78), Coutts, Basham, Hammond, Woolford, Sammon (Done 90), Sharp (Flynn 64). Subs not used: Howard, Baxter, Done, Adams
Wayne Rooney scored a last-minute penalty as a poor Manchester United edged League One Sheffield United to reach the FA Cup fourth round.
The hosts, 47 places above their opponents in the football pyramid, had only two shots on target throughout.
Substitute Memphis Depay curled just wide in the second half, but it looked like the visitors would earn a replay.
However, after Memphis was fouled inside the area, Rooney stepped up to score and send the hosts through.
Derby County 1-3 Manchester United
Friday 29th January
Derby: Thorne 37
Man Utd: Rooney 16, Blind 65, Mata 83
Derby: Carson, Christie, Keogh, Shackell, Warnock, Butterfield, Thorne (Russell 76), Johnson (Hendrick 76), Ince, Martin, Blackman (Camara 59). Subs not used: Olsson, Grant, Bryson, Baird.
Man United: De Gea, Varela, Smalling, Blind, Borthwick-Jackson, Schneiderlin (Carrick 74), Fellaini, Lingard, Mata (Herrera 84), Martial, Rooney. Subs not used: Romero, McNair, Pereira, Januzaj, Depay.
United relieved the pressure on manager Louis van Gaal by beating Derby in the FA Cup fourth round.
Van Gaal dismissed claims he offered to resign after losing to Southampton on Saturday, and his team were more positive against the Championship side.
Wayne Rooney curled in from 20 yards to put United ahead before George Thorne cut through their defence to equalise.
Daley Blind then finished low into the net from Jesse Lingard's cross before Juan Mata sealed victory late on.
Shrewsbury Town 0-3 Manchester United
Monday 21st February
Man Utd: Smalling 37, Mata 45, Libgard 61
Shrewsbury: Leutwiler, Grandison, Whitbread, Knight-Percival (Cole 46), Grimmer, Whalley, Ogogo, Black, Brown, Mangan, Akpa Akpro (Clark 80). Subs not used: Sadler, Vernon, Halstead, Smith, Grandin.
Man United: Romero, Varela, Smalling, Blind, Borthwick-Jackson (Riley 46), Schneiderlin, Herrera, Depay, Mata (Pereira 65), Lingard, Martial (Keane 71). Subs not used: Carrick, McNair, Poole, Henderson.
Manchester United made easy work of League One Shrewsbury Town to secure an FA Cup quarter-final with West Ham at Old Trafford.
United gave Louis van Gaal a comfortable night as they strolled into the last eight, with Chris Smalling's scuffed shot and Juan Mata's smart free-kick giving them a half-time advantage they never threatened to surrender.
Shrewsbury barely gave United an anxious moment - although Abu Ogogo had an effort scrambled off the line by United substitute Joe Riley as well as heading wide late on - and victory was wrapped up when Jesse Lingard turned in Ander Herrera's shot just after the hour.
Manchester United 1-1 West Ham United
Monday 13th March
Man Utd: Martial 83
West Ham: Payet 68
Man United: De Gea, Varela (Darmian 87), Smalling, Rojo, Blind, Carrick, Fellaini (Schweinsteiger 76), Lingard, Herrera, Martial, Rashford (Memphis 76). Subs not used: Romero, Williams, Schneiderlin, Januzaj.
West Ham: Randolph, Reid (Obiang 61), Ogbonna, Kouyate, Cresswell, Antonio, Noble, Lanzini, Payet, Emenike (Sakho 64), Carroll (Valencia 82). Subs not used: Adrian, Song, O'Brien, Moses.
Anthony Martial's late equaliser earned Manchester United an FA Cup quarter-final replay at West Ham United after Dimitri Payet's magnificent free-kick threatened to heap further misery on manager Louis van Gaal.
Payet's 68th-minute strike, curved high past United keeper David de Gea from 30 yards, looked to have put the Hammers on course for a semi-final at Wembley.
United, however, were revitalised by the introduction of Bastian Schweinsteiger for the struggling Marouane Fellaini and Martial ensured the teams would meet again at the Boleyn Ground with a far-post finish seven minutes from time.
West Ham United 1-2 Manchester United
Wednesday 13th April
West Ham: Tomkins 79
Man Utd: Rashford 54, Fellaini 67
West Ham: Randolph, Antonio, Tomkins, Ogbonna, Cresswell, Kouyate, Noble, Valencia (Moses 62), Lanzini (Emenike 74), Payet, Carroll. Subs not used: Adrian, Obiang, Collins, Hendrie, Oxford
Man Utd: De Gea, Fosu-Mensah, Smalling, Blind, Rojo (Valencia 68), Fellaini, Carrick, Lingard, Herrera (Schneiderlin 76), Martial, Rashford (Rooney 90). Subs not used: Romero, Mata, Young, Depay.
Manchester United reached the FA Cup semi-final after overcoming the Hammers in a replay.
Marcus Rashford gave Louis van Gaal's men the lead in this quarter-final replay after 54 minutes by curling a magnificent finish into the top corner past Darren Randolph.
And when Marouane Fellaini bundled in Martial's cross 13 minutes later it looked all over - only for West Ham to mount a fierce siege in the closing minutes.
Visiting keeper David de Gea, who gave a virtuoso display, had already saved superbly from Michail Antonio when James Tomkins stooped bravely among flying footwear to head in and give West Ham hope with 11 minutes left.
Manchester United 2-1 Everton
Saturday 23rd April
Man Utd: Fellaini 34, Martial 90+3
Everton: Smalling (o.g.) 75
Everton: Robles, Besic, Stones, Jagielka, Baines, McCarthy, Gibson (Mirallas 90mins), Lennon (Deulofeu 70), Barkley, Cleverley, Lukaku. Subs not used: Howard, Hibbert, Oviedo,Pennington, Osman.
Man United: De Gea, Fosu-Mensah (Valencia 62), Smalling, Blind, Rojo, Carrick, Lingard, Fellaini (Herrera 87), Rooney, Martial, Rashford. Subs not used: Romero, Depay, Darmian, Mata, Schneiderlin.
Marouane Fellaini gave United a deserved first-half lead from close range - but they were then indebted to goalkeeper David de Gea as he brilliantly saved Romelu Lukaku's 57th-minute penalty.
Everton rallied after a passive first 45 minutes that saw them jeered off at half-time and they drew level with 15 minutes left when Chris Smalling deflected Gerard Deulofeu's cross into his own net.
As the game looked destined for extra-time, Ander Herrera's poked pass sent Martial clear and the striker showed great composure to drill a low finish past Everton keeper Joel Robles.