Julian Speroni is set to equal John Jackson's Palace record of 388 appearances in all competitions as a goalkeeper as he has been named in the Eagles' side to face Southampton this afternoon.
The keeper is one of five changes from the side that beat Stoke City last weekend as Alan Pardew shuffles his pack with the FA Cup final now just six days away.
Adrian Mariappa comes in ahead of Scott Dann in defence, and Jordon Mutch get a start with Yannick Bolasie rested.
Mile Jedinak returns to skipper the side with Yohan Cabaye also given the afternoon off, and up front Emmanuel Adebayor is selected above Connor Wickham.
Youngsters Sullay Kaikai and Jake Gray have been named on the bench and could be in line to make their Premier League debuts.
Southampton meanwhile have made just one change to their line-up that beat Tottenham Hotspur last weekend, with Oriol Romeu coming in for the injured Jordy Clasie.
Southampton: Forster, Martina, Fonte, van Dijk, Bertrand, Romeu, Wanyama, Davis, Tadic, Mane, Long. Subs: Stekelenberg, Soares, Martina, Ward-Prowse, Reed, Pelle, Austin.
Palace: Speroni, Ward, Delaney, Mariappa, Souare, Puncheon, McArthur, Jedinak, Mutch, Adebayor, Gayle. Subs: McCarthy, Dann, Kelly, Lee, Gray, Kaikai, Campbell