After seeing off Blackpool in round two, Palace will now be aiming to continue their progress in this season's EFL Cup as they make the now-familiar trip to Southampton for tonight's game.
The Eagles have now faced the Saints in cup competition in each of the last three seasons, all of which have been on the south coast, and the previous two have seen Palace knock the hosts of the FA Cup in successive seasons.
Southampton though ran out comfortable 4-1 winners last May on their own turf when the sides last met, however much has changed since then with Ronald Koeman, Sadio Mane, Victor Wanyama and Graziano Pelle all departing during another summer reshuffle at the Saints.
Claude Puel has come in to replace the Dutch manager, and so far he has seen his side win just once in the league, which came on Sunday against Swansea City, but thy did beat Sparta Prague last Thursday in the Europa League.
Claude Puel: "It gave us confidence to get a second win of the week but I think we can do better by being more efficient.
“We had many chances [against Swansea] and it’s important to score more but it's positive because we played with different players. We kept our identity and played good football which is interesting for the future.
“You’ve got to prepare for the cup because it is important for the squad. Every game is difficult and the cup is always different. It’s important to play with the right attitude and a good spirit.”
Southampton: Puel made six changes from his side last week as they juggled Europa League football with the Premier League, so the likes of Maya Yoshida, Matt Targett, James Ward-Prowse and Charlie Austin could all be in line for starts.
However summer signings Sofiane Boufal and Jeremy Pied are already out injured long-term, and Jay Rodriguez is also struggling after picking up a knock.
Crystal Palace: Alan Pardew has suggested that he will be resting some players for this game, so after Connor Wickham and Bakary Sako returned to the bench for Sunday's win against Stoke City, both could be in contention for a starting spot, as well as the likes of Wayne Hennessey, Jordon Mutch and Chung-yong Lee.
Yohan Cabaye could also see some action if he shakes off a groin injury, but James Tomkins looks set for a spell on the sidelines after tweaking a knee against the Potters.
Pape Souare will be out for six months after his car crash, whilst Loic Remy will also be missing with a thigh injury.
HEAD TO HEAD
|Southampton wins||Draws||Palace wins|
The last two League Cup meetings between Southampton and Crystal Palace have ended 2-0 to the Eagles (1992 and 2011).
Southampton have won seven of their last 10 matches against Palace in all competitions (L3).
Palace have conceded a combined total of eight goals in their last two League Cup matches against fellow Premier League opponents, losing both matches.
The Saints have kept just one clean sheet (2-0 v Portsmouth in 2003) in their last 19 League Cup matches against Premier League opponents.
Southampton have reached the fourth round of the League Cup in each of the last five seasons, making the quarter-finals in each of the last two.
It's a first Palace appointment for James Adcock who mainly referees in the Championship, where he has overseen five matches this season, dishing out 22 bookings but not a red card.
Referee: J Adcock
Assistants: N Hopton and A Matthews
Fourth Official: J Linington
LAST MEETING AT ST MARY'S
15th May 2016
Southampton 4-1 Crystal Palace
Southampton qualified for the Europa League and ended the season with their highest Premier League points total with victory over Crystal Palace.
Sadio Mane opened the scoring late in the first half following a mistake by Palace keeper Julian Speroni.
Saints doubled the lead through substitute Graziano Pelle, but Jason Puncheon pulled one back for Palace.
Ryan Bertrand scored a penalty, before Steve Davis sealed the win with an emphatic late goal.
Tickets are still available to existing season ticket holders and paid members, at four per person.
Tickets will be priced at:
Adults - £12
Seniors (65+) - £10
Juniors (U18) - £5
Juniors (18-21) - £10
To purchase your tickets online, please click here.
Coaches departs at 3.30pm from Selhurst Park, priced at £15.
For directions on how to get to St Mary's, read our away travel guide here.
For more information on the ground, click here.
Live commentary of all the action from St Mary's will be available on Palace Player. Click HERE to log in or sign up.
There will also be constant updates throughout the day at @CPFC on Twitter.