Palace aim to equal their best ever run in the Premier League by picking up a fifth straight win as they head to St Mary's to take on Southampton in a 7.45pm kick-off.
While the Eagles have enjoyed cup success on the south coast in each of the past two seasons, Saints have lost just one of their last 13 home league meetings with the Eagles, winning the last five in a row.
However, Sam Allardyce has never lost a game at the ground and with his side filled with confidence, it could be a tough test for Claude Puel's team who drew 0-0 against their local rivals Bournemouth on Saturday.
That result left them just three points ahead of the resurgent Palace, having won one, drawn one and lost one of their three fixtures since they were defeated 3-2 in the EFL Cup final by Manchester United.
Claude Puel: "It's important now to find a good balance, to find a clinical edge because we haven't scored in the last game.
"Against Sunderland and Watford we found a good clinical edge. All of this is interesting, all the team took confidence. It's important to have a good feeling about this.
"You can score the first goal after the team can take confidence and it's better for the next game."
Southampton: January arrival Manolo Gabbiadini remains out with a groin injury picked up last month, while fellow attacker Sofiane Boufal is a doubt after getting injured in training.
Another transfer window acquisition in Martin Caceres is now fit enough for selection and could debut, but Virgil van Dijk, Charlie Austin, Matt Targett, Alex McCarthy and Jeremy Pied are out long-term.
Palace: Allardyce has confirmed that Scott Dann will be out for a few weeks with the knee injury that saw him stretchered off against Chelsea, while James Tomkins could miss this game and the subsequent game against Arsenal.
Patrick van Aanholt is still suffering from his ankle injury but Loic Remy will be back in the squad after being ineligible to play against the Blues on Saturday.
Connor Wickham (knee) and Pape Souare (leg) are the Eagles' only long-term injury casualties.
HEAD TO HEAD
|Southampton wins||Draws||Palace wins|
After failing to win any of their first 12 Premier League games against Southampton, the Eagles have won two of their last three against them, though both wins have come at Selhurst Park.
Southampton haven’t lost both league games in a season against Crystal Palace since 1990/91, when the Eagles finished third in the First Division.
Crystal Palace have won their last four Premier League games; they’ve only won five in a row in the competition on two other occasions (April 2014 and December 1992).
Sam Allardyce hasn’t won five consecutive matches in the Premier League as a manager since December 2006 while in charge of Bolton Wanderers.
Saints have won just once in their last five Premier League games at St. Mary’s, losing three (D1).
Wilfried Zaha has been directly involved in 13 Premier League goals this season (six goals, seven assists); three more than in his previous three top-flight campaigns combined (six goals, four assists).
Roger East has been handed just his ninth Premier League game of the campaign, the third of involving Southampton with the Saints winning neither of the previous two. He last oversaw Palace in their 0-0 FA Cup draw at Bolton Wanderers, with the Eagles winning six times in the 10 games of theirs that he has officiated.
Referee: R East
Assistants: A Holmes and M Scholes
Fourth official: L Probert
LAST MEETING AT ST MARY'S STADIUM
21st September 2016
Southampton 2-0 Crystal Palace
EFL Cup third round
Goals from Charlie Austin and Jake Hesketh saw Palace’s interest in the EFL Cup end at the third round as they were beaten at St Mary’s.
On a disappointing night for the Eagles, their exit at the hands of the Saints was compounded by Scott Dann being forced off injured early in proceedings, before Austin fired home a penalty just after the half-hour mark.
After Wayne Hennessey had helped his side stay in the tie by making a number of saves, he was beaten for a second time when Hesketh netted a rebound after another stop by the Welshman and saw Saints gain cup revenge over the Eagles, who had won at the venue twice in the FA Cup in successive seasons.
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