Sam Allardyce continues his search for a first win as Eagles manager against another of his former club as Palace travel to the London Stadium for the first time to take on the Hammers.
Slaven Bilic's men have endured a tough start to life in their new home, having won just four of their 10 league matches there, and currently sit 13th in the table after three wins in a row in December were followed by back-to-back defeats to Leicester City and Manchester United.
The Croatian has been handed a further headache with the news that Dimitri Payet is wanting to leave the club, and is unlikely to feature in this game having scored in both games against Palace last season.
The omens are good for the visitors as West Ham haven't won any of their last four home league games against the Eagles, last beating them in October 2003 at home.
Slaven Bilic: “We have a gap between us and the relegation zone, but we have to continue picking up points and be as safe as soon as possible. Everything will then look brighter.
“We have a chance on Saturday, a big game at home to a club below us and we want to win and be closer to mid-table.
“They have a good team and like us they are not in the position they planned or thought they would be. It happened to them last season when they had some ups and downs."
West Ham United: As well as Payet, Bilic has a number of other players unavailable for this game, with Cheikhou Kouyaté and Andrew Ayew away at the Africa Cup of Nations.
Gökhan Töre and Diafra Sakho are out long-term while Arthur Masuaku is also a doubt, however Michail Antonio could feature despite struggling recently through illness.
Simone Zaza looks to have played his last game for the Hammers as they are due to pay Juventus a fee for the striker as per the terms of his loan agreement, with Bilic not wanting to sign the Italian permanently.
Palace: Wayne Hennessey should return between the posts for Palace after missing the Bolton Wanderers game with a knock, while captain Scott Dann and James McArthur are closing in on returns.
Loic Remy could play some part after he came through 45 minute unscathed at the Macron Stadium, and Christian Benteke has recovered from a shoulder complaint.
Wilfried Zaha and Bakary Sako are away at the Africa Cup of Nations, while Steve Mandanda, Jonathan Benteke, Connor Wickham and Pape Souare remain out.
HEAD TO HEAD
|West Ham wins||Draws||Palace wins|
Palace have been victorious in just one of their last five league contests against the Hammers (D1 L3).
Sam Allardyce has been beaten just once in his last 10 Premier League games against former side West Ham (W5 D4 L1).
Manuel Lanzini has scored in all three of his Premier League games against the Eagles, but Yohan Cabaye has scored three goals in his last three Premier League matches against the Hammers.
Since he arrived in the Premier League, Dimitri Payet has created the most goalscoring chances (193) - a category he also leads in 2016-17 alone (74).
West Ham's only win in a London derby this season came at Selhurst Park (L3) while Palace have lost all four of their London derbies this season.
Neil Swarbrick is in charge of this game which could be lucky for Palace who have won both of their games he has officiated this season - the win at Middlesbrough and the 3-0 success over Southampton last month. The Eagles have won five and drawn four of the 15 matches he's been appointed to.
Referee: N Swarbrick
Assistants: P Kirkup and M Perry
Fourth official: R East
LAST MEETING AT WEST HAM
2nd April 2016
West Ham United 2-2 Crystal Palace
West Ham's hopes of qualifying for the Champions League were dented as they could only draw with Crystal Palace.
The Eagles went in front when Damien Delaney headed into the net from close range after a mistake from Adrian.
But the Hammers equalised three minutes later through Manuel Lanzini's low effort before Dimitri Payet's stunning 20-yard free-kick put the hosts ahead.
West Ham's Cheikhou Kouyate was sent off for fouling Dwight Gayle, who equalised after Angelo Ogbonna's error.
Tickets for this game are SOLD OUT.
For more information on how to get to the London Stadium, read our Away Day Guide here
For more information on the ground itself, please click here
Live commentary of the whole game at the London Stadium will be available on Palace Player. Click HERE to log in or sign up.
There will also be constant updates throughout the day at @CPFC
on Twitter, or you can get in-game stats and live coverage on our new official app - click here for more information.