Ayew replaces Jeffrey Schlupp in the side which began against Bristol City and joins last Saturday’s goalscorer Christian Benteke in a front two.
This is the only change that Hodgson has made to the XI which kicked off against the Robins.
The bench sees Development players Lewis Hobbs, Nikola Tavares, Luke Dreher and 17-year-old Brandon Pierrick join the first team as they continue their pre-season preparations.
For Hertha, former Chelsea man Salomon Kalou makes the starting XI and Liverpool loanee Marko Grujic joins him.
Palace: Guaita, Van Aanholt, Dann, Kelly, Ward, Meyer, Milivojevic, McArthur, Townsend, Ayew, Benteke.
Subs: Hennessey, Hobbs, Tavares, Riedewald, Dreher, Pierrick, Wickham.
Hertha: Jarstein, Rekik, Stark, Darida, Kalou, Duda, Klunter, Grujic, Mittelstadt, Ibisevic, Plattenhardt.
Subs: Kraft, Skjelbred, Lowen, Leckie, Fryde, Selke, Redan.