Ayew replaces Jeffrey Schlupp in the side which began against Bristol City and joins last Saturday’s goalscorer Christian Benteke in a front two.
This is the only change that Hodgson has made to the XI which kicked off against the Robins.
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The bench sees Development players Lewis Hobbs, Nikola Tavares, Luke Dreher and 17-year-old Brandon Pierrick join the first team as they continue their pre-season preparations.
For Hertha, former Chelsea man Salomon Kalou makes the starting XI and Liverpool loanee Marko Grujic joins him.
Palace: Guaita, Van Aanholt, Dann, Kelly, Ward, Meyer, Milivojevic, McArthur, Townsend, Ayew, Benteke.
Subs: Hennessey, Hobbs, Tavares, Riedewald, Dreher, Pierrick, Wickham.
Hertha: Jarstein, Rekik, Stark, Darida, Kalou, Duda, Klunter, Grujic, Mittelstadt, Ibisevic, Plattenhardt.
Subs: Kraft, Skjelbred, Lowen, Leckie, Fryde, Selke, Redan.