Wilfried Zaha and Jordan Ayew lead the line, with Michy Batshuayi joining on loan from Chelsea in time to make the matchday squad.
Jeffrey Schlupp and Andros Townsend will provide the width, with James McCarthy partnering James McArthur in the middle – club captain, Luka Milivojević, is on the bench after missing pre-season fixtures against Oxford United, Charlton Athletic and Millwall.
Tyrick Mitchell continues to deputise for Patrick van Aanholt at left-back, with Scott Dann, Cheikhou Kouyaté, Joel Ward and Vicente Guaita making up the defensive unit.
Former Palace ‘keeper Alex McCarthy starts for the Saints today, with Ralph Hasenhüttl selecting nine of the 11 that ended the season for Southampton, with Will Smallbone and Jan Bednarek coming in for Jan Vestergaard and Stuart Armstrong.
Palace: Guaita, Ward, Kouyaté, Dann, Mitchell, Townsend, McCarthy, McArthur, Schlupp, Ayew, Zaha
Subs: Hennessey, Kelly, Woods, Milivojević, Eze, Meyer, Batshuyai
Southampton: McCarthy, Walker-Peters, Stephens, Bednarek, Bertrand, Redmond, Romeu, Ward-Prowse, Smallbone, Adams, Ings
Subs: Forster, Vestergaard, Long, Djenepo, Obafemi, Tella, Vokins