The Belgian striker has been out of action since the start of September with a knee injury, but is back in contention today as a substitute as Hodgson rewards the same 11 players who earned a 2-0 win at Molineux last week with another start.
Watford meanwhile have made just a single change of their own from their side that drew 3-3 against Bournemouth 10 days ago, with Will Hughes replacing Ken Sema in midfield.
Palace: Guaita, Wan-Bissaka, Tomkins, Sakho, Van Aanholt, Kouyate, Milivojevic, McArthur, Zaha, Townsend, Ayew. Subs: Hennessey, Ward, Kelly, Schlupp, Meyer, Wickham, Benteke.
Watford: Foster, Femenia, Mariappa, Cathcart, Holebas, Doucoure, Capoue, Hughes, Pereyra, Deulofeu, Deeney. Subs: Gomes, Masina, Britos, Cleverley, Sema, Quina, Success.