Damien Delaney makes his first appearance since September as only one change to the backline that beat Southampton last time out, while Wilfried Zaha misses out with Patrick Van Aanholt deputising.
Meanwhile, Bakary Sako starts in attack in place of Christian Benteke, while Jairo Riedewald replaces Luka Milivojevic who drops to the bench alongside James Tomkins.
Chris Hughton has decided upon double the number of changes that Palace have, with only Ezquiel Schelotto, Dale Stephens and Jose Izquierdo surviving from the side that drew 2-2 with Bournemouth in their last fixture, with ex-Eagle Glenn Murray included on a strong bench for the Seagulls
Brighton: Krul, Schelotto, Goldson, Hunemeier, Bong, March, Stephens, Kayal, Izquierdo, Brown, Hemed. Subs: Maenpaa, Bruno, Dunk, Gross, Knockaert, Murray, Baldock.
Palace: Hennessey, Fosu-Mensah, Kelly, Delaney, Schlupp, Townsend, Cabaye, McArthur, Riedewald, Van Aanholt, Sako. Subs: Speroni, Souare, Wan-Bissaka, Tomkins, Milivojevic, Kaikai, Lee.