The on-loan Chelsea man comes into the side for Chung-yong Lee in what is the only switch to the Eagles line-up from last weekend’s 1-0 defeat to Burnley, with Hodgson opting against making wholesale changes.
Meanwhile James McArthur makes his 100th appearance for Palace, and James Tomkins and Bakary Sako return from injury to make the bench.
Saints boss Mauricio Pellegrino has decided to make four alterations to his side after they were beaten 2-0 by Watford at home seven days ago, and includes Virgil van Dijk on the bench.
Goals have been in short supply for Pellegrino’s men, and to try and rectify that Shane Long is preferred up front to Manolo Gabbiadini, with Dusan Tadic and club record signing Mario Lemina also brought back into the team in place of Sofiane Boufal and James Ward-Prowse.
Maya Yoshida also comes into the backline for Jack Stephens, and skipper Steven Davis makes his 200th appearance for the club.
Palace: Hennessey, Ward, Fosu-Mensah, Dann, Schlupp, Townsend, McArthur, Cabaye, Puncheon, Loftus-Cheek, Benteke. Subs: Speroni, Van Aanholt, Kelly, Tomkins, Milivojevic, Lee, Sako.
Southampton: Forster, Soares, Hoedt, Yoshida, Bertrand, Romeu, Davis, Lemina, Tadic, Redmond, Long. Subs: McCarthy, Targett, Stephens, Van Dijk, Ward-Prowse, Boufal, Gabbiadini.