The Norwegian attacker replaces the injured Wilfried Zaha at Goodison Park, while Joel Ward makes his first appearance since the start of December to replace Martin Kelly, with Timothy Fosu-Mensah moving to centre-half in the only switches from last weekend’s draw against Newcastle United.
Meanwhile, there could be further debuts as Erdal Rakip has been named on the bench for the Eagles, alongside Aaron Wan-Bissaka who is also awaiting a first-team bow.
Former Palace boss Sam Allardyce has made four alterations to his Toffees side after they were thrashed 5-1 at Arsenal last week, with Wayne Rooney returning to the starting XI as captain, as does Seamus Coleman, Tom Davies and Gylfi Sigurdsson.
That sees another man with red and blue connections drop to the bench as Yannick Bolasie will have to wait patiently for his chance, with Ashley Williams, Morgan Schneiderlin and Jonjoe Kenny all making way.
Everton: Pickford, Martina, Keane, Mangala, Coleman, Davies, Gueye, Walcott, Rooney, Sigurdsson, Niasse. Subs: Robles, Kenny, Williams, Schneiderlin, Bolasie, Calvert-Lewin, Tosan.
Palace: Hennessey, Ward, Fosu-Mensah, Tomkins, Van Aanholt, Townsend, McArthur, Milivojevic, Cabaye, Sørloth, Benteke. Subs: Henry, Wan-Bissaka, Souare, Delaney, Riedewald, Rakip, Lee.