You can watch how Mama fares live from 13:00 as he plays his first competitive match since being substituted against Norwich City on New Year's Day.
Sakho will kick-off at the centre of a strong Development defence - with Nikola Tavares and Tyrick Mitchell both having first-team experience from pre-season and substitute berths in the Premier League.
Elsewhere, Brandon Pierrick receives a starting place with 16-year-old John-Kymani Gordon up front.
To watch the Development lads live at 13:00, click here now! Gold, Junior Gold and International Members can watch this broadcast for free as part of their Membership.
Palace: Jacob Russell, Tavares, Mitchell, M.Boateng, Sakho, Rich-Baghuelou, Aveiro, McGregor, Gordon, Kirby, Pierrick.
Subs: Luthra, Flanagan, D.Boateng, Trialist, Street.