Ismaïla Sarr returns to the starting XI for the first time this season, with Daichi Kamada on the bench for this one.
Sage also makes a switch at right wing-back with Óscar Mingueza in from the off. Anan Khalaili is named amongst the substitutes.
And having missed recent domestic games through suspension, Axel Disasi returns to the defensive back three, next to Chris Richards and Jaydee Canvot.
With Dean Henderson still absent, Adam Wharton continues as captain, while Walter Benítez is between the sticks.
Having come off the bench to score in the last European tie, Eddie Nketiah is available as a substitute, as are Dwight McNeil and Darío Osorio.
Academy players Lucca Benetton and Dean Benamar have travelled with the squad and are both on the bench.
Lyon: Greif (GK), Vinicius, Kluivert, Bacher, Athekame, Morton, Nartey, Tolisso, Merah, Nuamah, Nakamura.
Subs: Bengul (GK), Descamps (GK), Bidstrup, Mata, Kamara, Tessmann, Kango, Niakhate, Duranville, Sulc, Nakamura, Boudache.
Palace: Benítez (GK), Disasi, Richards, Canvot, Mingueza, Timber, Wharton, Mitchell, Pino, Sarr, Strand Larsen.
Subs: Matthews (GK), Benetton (GK), Khalaili, Ahanor, Benamar, Hughes, McNeil, Kamada, Osorio, Nketiah.
Match Details
Olympique Lyonnais v Crystal Palace
- Thursday, 15th October
- 18:45 CEST / 17:45 BST kick-off
- UEFA Europa League
- Parc Olympique Lyonnais