Also among the 22 players also lining-up are Academy prospects John-Kymani Gordon, Tayo Adaramola, Seán Grehan, Kofi Balmer and Jack Wells-Morrison, who have each spent time with the first-team under Vieira.
There is also a return for Jack Butland after sustaining an injury earlier this year – he is expected to start in the second-half.
You can see the full teams below.
Botafogo travel to Selhurst as the first top-flight Brazilian club to play in SE25, with the likes of ex-Palace 'keeper Lucas Perri and former Manchester United man Rafael in their squad.
Palace first-half: Guaita (GK), Riedewald, Balmer, Tomkins, Clyne, Milivojević, Hughes, Olise, Zaha, Gordon, Edouard.
Palace second-half: Butland (GK), Adaramola, Phillips, Guéhi, Grehan, Doucouré, Wells-Morrison, Schlupp, Eze, Ebiowei, Mateta.
Botafogo: Perri (GK), Rafael, Adryelson, Cuesta, Marçal, Tchê, Pires, Fernandes, Sauer, Jeffinho, Soares.
Subs: D. Borges (GK), Gabriel (GK), Carli, Kanu, Sampaio, De Paula, Jacob, Valim, Piazon, Santos, Sá, Henrique.