Honest Ahanor comes into the Eagles XI, replacing Axel Disasi who serves the final game of his domestic suspension.
Daichi Kamada, who made a big impact of the bench against Lyon and has scored in his last two games, starts with Ismaïla Sarr reverting to the substitutes bench.
Sage has plenty of attacking options on his bench, with Jean-Philippe Mateta returning to the matchday squad for the first time since the opening day of the season. Jørgen Strand Larsen and Yéremy Pino keep their places in the starting line-up.
The final change sees Anan Khalaili return at right wing-back, replacing Óscar Mingueza who is named as a substitute.
Sage will also be able to call up the likes of Dwight McNeil, Darío Osorio and Eddie Nketiah from the bench, as he faces our fiercest rivals for the first time since joining Palace.
Brighton: Verbruggen (GK), Boscagli, Vuskovic, Dunk, De Cuyper, Ayari, Kadioglu, Andres, Gomez, Gross, Kostoulas.
Subs: Steele (GK), Hadjam, Svobada, Hinshelwood, Yalcouye, Costinha, O'Riley, Osman, Rutter.
Palace: Benítez (GK), Ahanor, Richards, Canvot, Khalaili, Timber, Wharton, Mitchell, Pino, Kamada, Strand Larsen.
Subs: Matthews (GK), Lerma, Mingueza, Hughes, McNeil, Osorio, Sarr, Nketiah, Mateta.
Brighton & Hove Albion v Crystal Palace
- Sunday, 18th October
- 14:00 BST
- Premier League
- Amex Stadium
- Live audio commentary on Palace TV+.