Skipper Dean Henderson misses out as he continues to manage a foot issue, meaning it's a second Premier League start for Argentine Walter Benítez in goal.
Honest Ahanor is in for his second consecutive game after also featuring against Middlesbrough in the Carabao Cup last Tuesday, he replaces Jaydee Canvot in defence.
And after his two goals against Boro in midweek, Jørgen Strand Larsen leads the line in the Palace attack, supported by Yéremy Pino and Daichi Kamada.
Adam Wharton will captain the team this afternoon in Henderson's absence, he is again partnered in midfield by Quinten Timber.
Ahanor is alongside Chris Richards and Axel Disasi in the defence, with Tyrick Mitchell and Anan Khalaili at wing-back.
Cheick Doucouré returns to the bench, where Sage will also be able to call upon Dwight McNeil and Zavier Gozo.
In a pre-match interview with BBC Sport, Sage said: "We knew that Eddie Nketiah was a doubt. We tried yesterday but his pre-match test was not good.
"For Jaydee Canvot, it was a sporting decision. And for our ‘keeper Dean Henderson, he was injured from the beginning of the season. He sustained an injury against Freiburg and now it’s too much for him [to play].
"He needs some recovery and he’ll maybe be back with us during the international break."
Palace: Benítez (GK), Ahanor, Richards, Disasi, Khalaili, Timber, Wharton, Mitchell, Pino, Kamada, Strand Larsen.
Subs: Matthews (GK), Chilwell, Mingueza, Tomiyasu, Lerma, Hughes, Doucouré, McNeil, Gozo.
Ipswich: Scherpen (GK), O'Shea, Diop, Greaves, Davis, Palacios, Lukic, Fatawu, Enciso, Clarke, Emersonn.
Subs: Walton (GK), Kipre, Ouattara, Florentino, Nunez, Philogene, Maeda, Akpom, Flemming.
Crystal Palace v Ipswich Town
- Saturday, 12th September
- 15:00 BST
- Premier League
- Selhurst Park
- Live audio commentary on Palace TV+.