Usual order is restored to Palace’s backline, with Joel Ward and Scott Dann back from injury, replacing Martin Kelly and Adrian Mariappa who deputised in midweek.
Jason Puncheon, Yannick Bolasie and Connor Wickham who were rested for the game against Manchester United are the other three changes, with Joe Ledley, Bakary Sako and Emmanuel Adebayor dropping to the bench.
Although he has fought tirelessly to get back to full fitness for the last few games of the season, James McArthur is only named as a substitute.
Watford name an almost completely changed team from the side who lost to West Ham in their own midweek fixture. Manager Quique Sánchez Flores brings back attacking duo Troy Deeney and Odion Ighalo, and also starts with goalkeeper Costel Pantilimon (who has played in every one of Watford’s FA Cup games), despite first choice keeper Heurelho Gomes saving two penalties in their league victory away to West Brom last weekend.
The Hornet's only enforced change to the matchday squad is Nordin Amrabat, who is serving a one game ban.
Palace: Hennessey, Ward, Dann, Delaney, Souare, Puncheon, Cabaye, Jedinak, Zaha, Bolasie, Wickham. Subs: Speroni, Kelly, McArthur, Ledley, Sako, Gayle, Adebayor.
Watford: Pantilimon, Nyom, Britos, Cathcart, Ake, Abdi, Capoue, Watson, Jurado, Deeney, Ighalo. Subs: Gomes, Prodl, Anya, Guedioura, Suarez, Berghuis, Behrami.