Cheikhou Kouyaté comes in for his first Premier League minutes of the season, whilst Jeffrey Schlupp makes his first start of the campaign having returned to league action in the second-half of the Blades defeat.
There’s an Eagles debut for Gary Cahill, with the summer signing coming in for Scott Dann at the heart of the defence.
Jordan Ayew returns to lead the line, with Christian Benteke dropping to the bench after starting the first two games of the season.
Manchester United have kept the same line-up that started their away day draw to Wolverhampton Wanderers.
Palace: Guaita, Ward, Kelly, Cahill, Van Aanholt, Kouyaté, McArthur, Milivojevic, Schlupp, Zaha, Ayew. Subs: Hennessey, Meyer, Townsend, Dann, Benteke, Wickham, McCarthy.
Manchester United: De Gea, Wan-Bissaka, Maguire, Lindelöf, Shaw, McTominay, Pogba, Lingard, James, Rashford, Martial. Subs: Romero, Greenwood, Tuanzebe, Matić, Young, Mata, Pereira.