Jordan Ayew joins the duo in attack with Zaha unavailable, ahead of Luka Milivojevic, Conor Gallagher and James McArthur in midfield.
Patrick Vieira has elected for a familiar back five for the Eagles, with Joachim Andersen and Marc Guehi in central defence, Joel Ward and Tyrick Mitchell out wide, and Vicente Guaita in goal.
The hosts name a strong side, with Martin Ødegaard, Emile Smith Rowe, Bukayo Saka, Pierre-Emerick Aubameyang and Nicolas Pepe - who scored twice the last time the two sides met - lining up in the forward positions.
Palace: Guaita (GK), Ward, Guehi, Andersen, Mitchell, Milivojevic, McArthur, Gallagher, Benteke, Edouard, Ayew.
Subs: Butland (GK), Tomkins, Olise, Kouyate, Hughes, Mateta, Schlupp, Clyne.
Arsenal: Ramsdale (GK), Tierney, White, Partey, Gabriel, Saka, Ødegaard , Smith Rowe, Aubameyang, Tomiyasu, Pepe.
Subs: Leno (GK), Lacazette, Maitland-Niles, Holding, Soares, Tavares, Lokonga, Elneny, Martinelli.