This trio will form part of Shaun Derry's XI in a 14:00 GMT kick-off which you can watch live - find out more information here.
Tomkins will complete his first minutes since 2019/20 as he continues to make positive steps towards full fitness. Kelly and Benteke share over 600 professional appearances between them and will provide huge boosts to the Development side's hunt for three points.
Palace will feel confident taking on the visiting Wolves after collecting their first win of the season recently against Burnley.
They also field Scott Banks, Sam Woods and Brandon Pierrick, with 17-year-old Noah Watson handed a start, too.
Don't miss the lads in action alongside Benteke, Kelly and Tomkins and watch them live here!
Palace: Webber, Kelly, Woods, Tomkins, D.Boateng, Watson, M.Boateng, Banks, Spence, Pierrick, Benteke.
Subs: Jacob Russell, Baghuelou, Tavares, Flanagan, Street.
Wolves: Sondergaard, Burr, Estrada, Marques, Ngolou, Bueno, Ferraira, Cundle, Corbeanu, Otasowie, Shabani.
Subs: Perry, Carty, Matheson, Nya, Campbell.
READ NEXT: Watch Palace U23s battle Wolves LIVE today