Ruben Loftus-Cheek, Jairo Riedewald and Timothy Fosu-Mensah are all included for Palace, with the latter two part of a three-man defence, allowing Luka Milivojevic to move back into central midfield alongside new captain Jason Puncheon.
Joel Ward and Patrick van Aanholt feature as wing-backs, with Loftus-Cheek is pushed forward into attack alongside Wilfried Zaha and Christian Benteke.
Ahead of their first ever Premier League match, Huddersfield boss David Wagner has included seven of his new recruits in his starting XI, with club record signing Steve Mounie starting up front.
Tom Ince returns to Selhurst Park for the first time since his loan spell with the Eagles in 2014, while Tommy Smith captains the Terriers for the maiden time in an official capacity following the retirement of Mark Hudson earlier this week.
Palace: Hennessey, Fosu-Mensah, Dann, Riedewald, Ward, Milivojevic, Puncheon, Van Aanholt, Loftus-Cheek, Zaha, Benteke. Subs: Speroni, Schlupp, Tomkins, Lee, Lokilo, Townsend, Ladapo.
Huddersfield: Lossl, Smith, Jorgensen, Schindler, Lowe, Mooy, Billing, Kachunga, Ince, Palmer, Mounie. Subs: Coleman, Malone, Hefele, Van La Parra, Williams, Depoitre, Quaner.