Both players have suffered knee injuries and will be unavailable for selection at Selhurst Park, manager Oliver Glasner said in his pre-match press conference.
There was, however, a promising update with regards to Matheus França, who Glasner confirmed has been training with the first-team after being in recovery thus far in 2024/25.
Glasner said: “Unfortunately Cheick Doucouré and Chadi Riad both have knee injuries and aren’t available for Sunday’s game.
“The doctors have to look at them, and let’s see how it goes, but no [we don’t have a timeframe for their return] at the moment.
“Joel Ward is still out, Adam Wharton is still out.
“França is training with us, but still needs more time on the pitch to get into his best shape, so he won’t be available.
“All the others who were involved in the last games are ready.”
The manager also confirmed that new arrival Romain Esse – who signed for the club last week from Millwall – would be named in the matchday squad.
"He's a great profile, a great guy, everything we were looking for," Glasner said. "Now it's our job to work with him to integrate him.
"It's the first time he will be in the squad with us. He's doing really well in training."
Match Details
- Crystal Palace v Brentford
- Sunday, 26th January
- 14:00 GMT
- Premier League
- Selhurst Park
- Live audio commentary on Palace TV+